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Ki Churl Chang Selected Research

higenamine (norcoclaurine)

5/2012Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways.
7/2008Enantioselective synthesis of (R)-(+)- and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation.
7/2006Higenamine reduces apoptotic cell death by induction of heme oxygenase-1 in rat myocardial ischemia-reperfusion injury.
2/2006Enantiomers of higenamine inhibit LPS-induced iNOS in a macrophage cell line and improve the survival of mice with experimental endotoxemia.
4/2002The effects of higenamine on LPS-induced experimental disseminated intravascular coagulation (DIC) in rats.

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Ki Churl Chang Research Topics

Disease

23Inflammation (Inflammations)
01/2018 - 08/2003
17Sepsis (Septicemia)
01/2018 - 07/2009
15Neoplasms (Cancer)
07/2019 - 08/2003
12Atherosclerosis
09/2015 - 03/2007
11Ischemia
01/2018 - 02/2006
9Reperfusion Injury
10/2012 - 07/2006
9Myocardial Ischemia (Ischemic Heart Diseases)
01/2012 - 07/2006
8Infarction (Infarctions)
08/2009 - 01/2008
7Breast Neoplasms (Breast Cancer)
07/2019 - 09/2008
7Glioblastoma (Glioblastoma Multiforme)
09/2014 - 08/2008
6Neoplasm Metastasis (Metastasis)
03/2015 - 09/2008
6Wounds and Injuries (Trauma)
07/2014 - 01/2006
5Hypoxia (Hypoxemia)
07/2015 - 09/2007
3Septic Shock (Toxic Shock Syndrome)
01/2013 - 05/2002
3Hypertension (High Blood Pressure)
09/2011 - 03/2008
3Multiple Organ Failure (MODS)
07/2008 - 04/2002
3Disseminated Intravascular Coagulation
07/2008 - 04/2002
2Infections
12/2016 - 04/2012
2Non-alcoholic Fatty Liver Disease
10/2016 - 11/2014
2Insulin Resistance
10/2016 - 11/2009
2Lung Neoplasms (Lung Cancer)
03/2015 - 05/2007
2Hepatocellular Carcinoma (Hepatoma)
11/2014 - 06/2014
2Brain Neoplasms (Brain Tumor)
01/2014 - 10/2012
2Brain Infarction
05/2012 - 12/2008
2Endotoxemia
07/2009 - 02/2006
2Carcinogenesis
10/2008 - 09/2008
2Carcinoma (Carcinomatosis)
09/2008 - 06/2004
2Vascular Diseases (Vascular Disease)
03/2008 - 11/2007
1Acute Lung Injury
05/2018
1Acute Kidney Injury (Acute Renal Failure)
01/2018
1Skin Neoplasms (Skin Cancer)
07/2017

Drug/Important Bio-Agent (IBA)

17HMGB1 Protein (HMG1)IBA
05/2018 - 07/2009
9CytokinesIBA
01/2018 - 07/2009
9Heme Oxygenase-1IBA
11/2017 - 07/2006
9AlkaloidsIBA
11/2017 - 04/2002
8YS 49IBA
03/2015 - 05/2002
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2016 - 02/2006
6Proteins (Proteins, Gene)FDA Link
12/2018 - 10/2008
6LipopolysaccharidesIBA
06/2014 - 01/2004
6Pharmaceutical PreparationsIBA
01/2014 - 05/2007
6Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
11/2013 - 07/2006
51,2,3,4-tetrahydroisoquinolineIBA
11/2017 - 04/2002
5Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
01/2014 - 09/2008
5Anthocyanins (Anthocyanin)IBA
10/2012 - 02/2006
5higenamine (norcoclaurine)IBA
05/2012 - 04/2002
4Adenosine Triphosphate (ATP)IBA
07/2015 - 07/2014
4CollagenIBA
07/2015 - 06/2010
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2015 - 11/2009
4Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
01/2011 - 05/2002
4NF-kappa B (NF-kB)IBA
07/2009 - 02/2006
3isoquinolineIBA
10/2016 - 05/2002
3EnzymesIBA
07/2015 - 06/2004
3NucleotidesIBA
07/2015 - 08/2014
3Paclitaxel (Taxol)FDA LinkGeneric
09/2014 - 10/2008
3Small Interfering RNA (siRNA)IBA
08/2014 - 10/2008
3Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
04/2012 - 03/2007
3PPAR gammaIBA
12/2009 - 10/2006
3AntioxidantsIBA
11/2009 - 06/2004
3Dacarbazine (DIC)FDA LinkGeneric
07/2008 - 04/2002
3Oxidants (Oxidizing Agents)IBA
11/2007 - 01/2006
31- (beta- naphthylmethyl)- 6,7- dihydroxy- 1,2,3,4- tetra- hydroisoquinoline (YS 51)IBA
06/2004 - 05/2002
2BerberineIBA
07/2019 - 08/2003
2EndotoxinsIBA
05/2018 - 05/2002
2Sirtuin 1IBA
01/2018 - 10/2016
2Hemin (Panhematin)FDA Link
07/2017 - 07/2009
2DNA-Binding Proteins (DNA Binding Protein)IBA
02/2017 - 01/2013
2Triglycerides (Triacylglycerol)IBA
10/2016 - 11/2014
2Glucose (Dextrose)FDA LinkGeneric
10/2016 - 05/2012
2Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA
07/2015 - 10/2014
2Uridine Triphosphate (UTP)IBA
10/2014 - 07/2014
2Purinergic P2Y2 ReceptorsIBA
08/2014 - 04/2014
2honokiolIBA
01/2014 - 10/2012
2p38 Mitogen-Activated Protein KinasesIBA
11/2013 - 05/2013
2Cell Adhesion MoleculesIBA
04/2012 - 10/2008
2DexmedetomidineFDA Link
09/2011 - 05/2011
2Carbon MonoxideIBA
06/2011 - 07/2009
2LigandsIBA
06/2010 - 07/2009
2PPAR deltaIBA
06/2010 - 07/2009
2tricarbonyldichlororuthenium (II) dimerIBA
12/2009 - 07/2009
2Prostaglandins EIBA
12/2009 - 10/2008
2Superoxide DismutaseIBA
08/2009 - 06/2004
2bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA
04/2009 - 10/2008
2N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA
11/2008 - 09/2007
2tanshinoneIBA
10/2008 - 09/2008
2paeonolIBA
01/2008 - 03/2007
1Biological ProductsIBA
07/2019
1Transcription Factor 3IBA
12/2018
1Aldehyde Dehydrogenase 1 FamilyIBA
12/2018
1LuteolinIBA
05/2018
1AlarminsIBA
01/2018
1Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
01/2018
1Lysine (L-Lysine)FDA Link
01/2018
1Histones (Histone)IBA
02/2017
1AMP-Activated Protein KinasesIBA
11/2016
1Cell Adhesion Molecule-1IBA
10/2016

Therapy/Procedure

6Ligation
10/2014 - 01/2008
5Punctures
10/2014 - 07/2009
2Radiotherapy
07/2019 - 12/2018
2Anesthesia
10/2008 - 01/2008
1Drug Therapy (Chemotherapy)
12/2018